Brain-derived neurotrophic factor in depression: a male problem?
نویسندگان
چکیده
منابع مشابه
Brain-Derived Neurotrophic Factor for Depression Therapeutics
Increasing evidence over the last two decades has indicated that the pathophysiology of Major Depressive Disorder (MDD) and the action of antidepressants both involve Brain-Derived Neurotrophic Factor (BDNF), a major neuronal growth factor in the brain. MDD is a complex disorder that results from genetic and environmental influences, singly or in combination. This article reviews the current kn...
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Background: Depression is often viewed as a risk factor for the development of Alzheimer’s disease (AD), however little is known regarding the underlying biological mechanisms linking these two diseases. Brain-derived neurotrophic factor (BDNF) has been linked to both cognitive impairment and depression in past research; however few studies have examined this relation in a sample of Alzheimer’s...
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Depression and suicidal behavior have recently been shown to be associated with disturbances in structural and synaptic plasticity. Brain-derived neurotrophic factor (BDNF), one of the major neurotrophic factors, plays an important role in the maintenance and survival of neurons and in synaptic plasticity. Several lines of evidence suggest that BDNF is involved in depression, such that the expr...
متن کاملPlasma brain-derived neurotrophic factor in bipolar and unipolar depression
Objective There is increasing evidence that BrainDerived Neurotrophic Factor may be involved in the pathophysiology of depression and the actions of antidepressants. At the same time, the differential diagnosis between unipolar and bipolar depression is often a challenge with important treatment implications. The aim of the present study was to analyze the relationship between BrainDerived Neur...
متن کاملDecreased Levels of Serum Brain-Derived Neurotrophic Factor in Male Pediatric Patients with Depression
Background: Brain-derived neurotrophic factor (BDNF) plays an important role in the pathophysiology of major depressive disorder (MDD). Several meta-analyses have shown decreased serum levels of BDNF in adult patients with MDD, but there has been no report on the serum levels of BDNF in pediatric patients with depression. In this study, we investigated whether serum levels of BDNF are altered i...
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ژورنال
عنوان ژورنال: Molecular Psychiatry
سال: 2010
ISSN: 1359-4184,1476-5578
DOI: 10.1038/mp.2010.19